The Center for the Biology of Chronic Disease

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Ramji L. Khandelwal, PhD

Professor, Department of Biochemistry, University of Saskatchewan, Canada

COMMENTS

This is an excellent book that provides published data from a very different perspective to formulate a generalized theory in terms of stable good health. In this theory, under normal good health conditions, a disturbance to a system returns to the same equilibrium. Any deviation from good health results in chronic disease. The basic concepts are well presented in chapters dealing with "Technical Notes." These are then explored with published results on chronic diseases. A chapter on treatment outlines reversal from an abnormal equilibrium towards a normal equilibrium. This is an excellent book that describes a good health/chronic disease in terms of dynamic equilibrium with the basic premise "microcompetition with foreign DNA causes chronic diseases." This is right on the target and deserves to be examined further. I am confident that this theory will be validated with future work. It has already provided stimulus to my thinking, and so far, I agree with the basic concepts outlined in this book. My work was well described and Dr. Polansky deserves a big thank you for this. Thank you again to give me a chance to review the book and to provide comments.

BIOGRAPHY

Dr. Ramji L. Khandelwal obtained his PhD from the University of Manitoba and then was trained as a postdoctoral fellow in the laboratory of Nobel Laureate Dr. Edwin G. Krebs at the University of California, Davis. At present, he is Professor and Head of the Department of Biochemistry at the University of Saskatchewan. His research interests are to delineate aberrations that occur in diseased states, especially in diabetes. He is also working on the interrelationship between insulin and tumor necrosis factor-alpha and how they modulate insulin signaling pathways.

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